TORADOL (Ketorolac) is used for the short-term treatment of moderate to severe pain in adults, usually after surgery. Reducing pain helps you recover more comfortably from surgery and return to your normal daily activity sooner. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).
TORADOL (Ketorolac) should not be used for mild or ongoing painful conditions.
TORADOL (ketorolac tromethamine) is a member of the pyrrolo-pyrrole group of 65 nonsteroidal anti-inflammatory drugs (NSAIDs). The chemical name for ketorolac 66 tromethamine is (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, compound 67 with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
Ketorolac tromethamine is a racemic mixture of [-]S and [+]R ketorolac tromethamine. Ketorolac tromethamine may exist in three crystal forms. All forms are equally soluble in water. Ketorolac tromethamine has a pKa of 3.5 and an n-octanol/water partition coefficient of 0.26. The molecular weight of ketorolac tromethamine is 376.41. Its molecular formula is C19H24N2O6. TORADOL ORAL is available as round, white, film-coated, red-printed tablets. Each tablet contains 10 mg ketorolac tromethamine, the active ingredient, with added lactose, magnesium stearate and microcrystalline cellulose. The white film-coating contains hydroxypropyl methylcellulose, polyethylene glycol and titanium dioxide.
The tablets are printed with red 78 ink that includes FD&C Red #40 Aluminum Lake as the colorant. There is a large T printed on both sides of the tablet, as well as the word TORADOL on one side, and the word ROCHE on the other.
Learn all preparation and usage instructions in the product package. If any of the information is unclear, consult your doctor or pharmacist.
Treatment with TORADOL (ketorolac) tablets should usually be started only after you have already been given the injectable form of ketorolac. The Canadian manufacturer states that the tablets may be used even if you have not received ketorolac injection. If you have been prescribed ketorolac by mouth without first receiving ketorolac injection, promptly consult your doctor or pharmacist before taking this medication. Though it is very unlikely to occur, a severe allergic reaction is possible after taking the first dose. (See Side Effects.)
Take this medication by mouth, usually every 4 or 6 hours with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 30 minutes after taking this drug. Take it with food, milk, or an antacid to prevent stomach upset.
Dosage is based on your medical condition and response to therapy. To reduce side effect risks (e.g., stomach bleeding), use this medication at the lowest effective dose for the shortest possible time. Do not increase your dose, take it more often than prescribed, or use it for more than 5 days in total (injection and tablets). Do not take more than 40 milligrams per day of ketorolac by mouth. Discuss the risks and benefits with your doctor or pharmacist.
If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has significantly worsened, the medicine may not work as well.
Inform your doctor if your condition persists or worsens
Carefully consider the potential benefits and risks of TORADOL and other treatment options before deciding to use TORADOL. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. In adults, the combined duration of use of IV or IM dosing of ketorolac tromethamine and TORADOL ORAL is not to exceed 5 days. In adults, the use of TORADOL ORAL is
only indicated as continuation therapy to IV or IM dosing of ketorola tromethamine.
Transition from IV or IM dosing of ketorolac tromethamine (single- or multiple dose) to multiple-dose TORADOL ORAL:
Patients age 17 to 64: 20 mg PO once followed by 10 mg q4-6 hours prn not >40 mg/day
Patients age ≥65, renally impaired, and/or weight <50 kg (110 lbs): 10 mg PO once followed by 10 mg q4-6 hours prn not >40 mg/day
Oral formulation should not be given as an initial dose
Use minimum effective dose for the individual patient
Do not shorten dosing interval of 4 to 6 hours
Total duration of treatment in adult patients: the combined duration of use of IV or IM dosing of ketorolac tromethamine and TORADOL ORAL is not to exceed 5 days.
Toradol Oral Missed Dose
If you are prescribed this drug on a regular schedule (not just "as needed") and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Toradol Oral Storage
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Toradol and seek medical attention or call your doctor at once if you have any of these serious side effects:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
swelling or rapid weight gain;
urinating less than usual or not at all;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
the first sign of any mouth sores or skin rash, no matter how mild;
pale skin, easy bruising, severe tingling, numbness, pain, muscle weakness; or
fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).
Less serious side effects may include:
upset stomach, nausea, vomiting, diarrhea, constipation;
mild heartburn, stomach pain, bloating, gas;
dizziness, headache, drowsiness;
ringing in your ears.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
The following medications may affect the way that ketorolac works or increase the risk of side effects:
angiotensin converting enzyme (ACE) inhibitors (e.g., ramipril)
beta-adrenergic blockers (e.g.,metoprolol, atenolol)
corticosteroids (e.g., prednisone)
diuretics (water pills; e.g., spironolactone, triamterene)
other NSAIDs (e.g., naproxen, diclofenac)
Ketorolac may affect the way that the following medications work:
aminoglycosides (e.g., amikacin, gentamycin, tobramycin)
diuretics (water pills; e.g., furosemide, hydrochlorothiazide)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
TORADOL ORAL 10 mg tablets are round, white, film-coated, red printed tablets. There is a large T printed on both sides of the tablet, with TORADOL on one side, and ROCHE on the other.
- How To Use Toradol
- Dosage and Administration
- Side Effects
- Drug Interactions
- How Supplied